Abcam, ab33866, Anti-MKK6 antibody [EP557Y]

Size: 100µL
Rabbit Monoclonal MP2K6 antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP557Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MKK6 also known as MAP2K6 functions as a dual-specificity kinase within cellular signaling processes. It belongs to the MAP kinase kinase (MAP2K) family and specifically activates p38 MAP kinase by phosphorylation. This protein weighs approximately 38 kDa and is expressed in various tissues with higher levels often found in the brain heart and skeletal muscle. MKK6 plays a significant role in transmitting signals that regulate cellular responses to stress and inflammation.
Biological function summary
This protein modulates important cellular mechanisms by acting as an important component of the p38 MAPK signaling cascade. It interacts with other kinases to form signaling complexes that mediate responses like cell growth division and apoptosis. MKK6 becomes activated in response to environmental stressors and cytokines triggering a phosphorylation cascade that concludes with the activation of p38 MAPK which then enters the nucleus to influence gene expression.
Pathways
MKK6 integrates into the MAPK signaling pathway particularly in stress response and inflammatory signaling pathways. The protein activates p38 MAPK an important player in these pathways and associates with other proteins such as MKK3 and MKK4 to regulate diverse cellular activities. This activation is a part of well-established pathways like cytokine production and response to DNA damage offering comprehensive regulation of cellular homeostasis.
MKK6 involvement links to inflammatory conditions and stress-related pathologies. It has been implicated in diseases like rheumatoid arthritis where its activity relates to increased inflammatory responses and also in cancer contributing to tumor growth and survival via p38 MAPK activation. Through these conditions MKK6 connects closely with other proteins within the MAPK pathway including p38 MAPK which plays a role in the alteration of cellular proliferation and apoptosis often observed in pathological states.