Abcam, ab3432, Anti-SCAMP5 antibody

Size: 100µg
Rabbit Polyclonal SCAMP5 antibody. Suitable for WB and reacts with Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Rat Scamp5 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Rat Scamp5 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9JKE3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCAMP5 also known as Secretory Carrier Membrane Protein 5 plays an important role in vesicular trafficking. This protein has a molecular weight of approximately 38 kDa and is primarily expressed in the nervous system especially in neurons. SCAMP5 localizes mainly to synaptic vesicles where it engages in the regulation of exocytosis. It functions in membrane trafficking by facilitating vesicle fusion and recycling which is essential for neural communication.
Biological function summary
SCAMP5 influences synaptic transmission and neuronal signaling. It participates in the exocytic machinery required for neurotransmitter release. SCAMP5 integrates into membrane complexes that include proteins involved in vesicle docking and fusion. The presence of SCAMP5 in these complexes underlines its importance in maintaining efficient synaptic function. Additionally its expression is linked to neural differentiation and plasticity.
Pathways
Neurons employ SCAMP5 within the synaptic vesicle cycle and neurotransmitter release pathways. SCAMP5 collaborates with proteins such as synaptotagmin and SNARE proteins to ensure precise synaptic vesicle fusion with the presynaptic membrane. This coordination is essential for maintaining synaptic transmission efficiency and plasticity. The interaction within these pathways showcases SCAMP5's role in neurotransmitter regulation and highlights its position in neural activity modulation.
SCAMP5 associates with neurological conditions such as epilepsy and schizophrenia. Abnormalities in SCAMP5 expression or function can lead to disrupted synaptic processes. It exhibits connections with proteins like synaptophysin which also affect synaptic vesicle dynamics. Understanding SCAMP5's role in these disorders may prove helpful in developing therapeutic strategies targeting synaptic dysfunction.