Abcam, ab36001, Anti-CGRP antibody

Size: 100µL
Anti-CGRP antibody (ab36001) is a goat polyclonal antibody detecting CGRP in IHC-P, IHC-Fr, ELISA . Suitable for Mouse, Rat . - Over 140 publications - Trusted since 2006
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:ELISA, IHC-Fr, IHC-FoFr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Antibody is thought to react with whole molecule (1-37) and 23-37 fragment (C term). Specifically visualises CGRP in brain cells.

Product details:
Product Specifications
Anti-CGRP antibody (ab36001) is a goat polyclonal antibody and is validated for use in ELISA, IHC-FoFr, IHC-Fr, IHC-P in mouse, rat samples.
Anti-CGRP antibody (ab36001) specifically detects CGRP (UniProt ID: P01256; Molecular weight: 14kDa) and is sold in 100 µL selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-CGRP antibody (ab36001) has high sensitivity and specificity.
Anti-CGRP antibody (ab36001) has been cited over 144 times in peer reviewed journals and is trusted by the scientific community.
Anti-CGRP antibody (ab36001) has 12 independent reviews from customers.
Target Information
CGRP (Calcitonin Gene-Related Peptide) is a significant neuropeptide extensively studied in neuroscience. Its role is particularly noted in various neurodegenerative conditions, including Alzheimer's disease (AD). CGRP is involved in modulating inflammation and neuroprotection, making it a valuable marker for assessing neuroinflammatory responses. In AD, changes in CGRP expression can provide insights into the disease's progression and the associated inflammatory processes. This highlights CGRP's importance in understanding and potentially targeting neuroinflammation.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified Ig by Ammonium Sulphate fractionation., Storage buffer-pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CGRP or Calcitonin Gene-Related Peptide is a 37-amino acid neuropeptide with a molecular mass of approximately 3.8 kDa. This peptide exists mainly in two forms alpha-CGRP and beta-CGRP differing slightly in amino acid sequence. CGRP expresses in peripheral and central nervous systems with high levels in the dorsal root ganglia and thyroid gland. It also has a significant presence in the enteric nervous system and some segments of the cardiovascular system. Scientists note that CGRP acts as a potent vasodilator and plays a significant role in transducing pain signals.
Biological function summary
CGRP contributes to numerous physiological processes including blood flow regulation body temperature control pain transmission and neurogenic inflammation. It acts independently and does not substantially form part of larger protein complexes in its primary activities. Through binding to the CGRP receptor a complex made up of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) CGRP initiates downstream signaling that results in its various biological effects.
Pathways
Studies place CGRP within the neuropeptide signaling pathway and the vasodilation pathway. It significantly influences the cyclic AMP (cAMP) signaling pathway where it works collaboratively with other neuropeptides like substance P. The interaction with CLR and RAMP1 triggers the production of cAMP which enhances vasodilation and pain transmission processes in the body.
CGRP holds a notable connection to migraines and cardiovascular diseases. Elevated CGRP levels are observed in migraine sufferers and targeted treatments utilizing anti-CGRP antibodies have demonstrated efficacy in reducing migraine frequency. Additionally research links CGRP to blood pressure regulation abnormalities implicating its involvement in hypertension. Both conditions involve complex interactions with other proteins such as substance P and endothelial nitric oxide synthase (eNOS) which modulate vascular tone and inflammation.