Abcam, ab36385, Anti-C3a / C3a des Arg antibody [K13/16]

Size: 100µg / 100µL
Mouse Monoclonal C3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 9 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:K13/16,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Epitope:Recognizes an epitope present on human C3, C3a and C3a(desArg).,
Specificity:Does not cross react with C4a or C5a.

Product details:
Effectively inhibits the biological activity of C3a in a guinea-pig platelet activation assay.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C3a also known as C3a des Arg or C3a full form is a small peptide anaphylatoxin derived from the complement component C3. It plays an important mechanical role in the immune system by acting as a potent mediator of inflammation. C3a weighs approximately 9 kDa. It expresses primarily on the surface of immune cells such as mast cells and basophils. The function of C3a involves the binding to the C3a receptor (C3aR) triggering a series of immune responses.
Biological function summary
C3a serves as an essential inflammatory agent and is part of the complement system an important component of the innate immune response. It contributes to the defense against pathogens by promoting chemotaxis degranulation and the release of histamine. C3a desArg a derivative of C3a generated by the removal of the C-terminal arginine residue has reduced inflammatory activity. The activity of C3a and its link to inflammation highlights its importance in maintaining immune homeostasis and responding to infectious threats.
Pathways
C3a plays an important role in the complement activation cascade particularly the classical and alternative pathways. This involvement highlights its relationship with proteins such as C3b and C5 which are critical in the opsonization and membrane attack complex formation. C3a's role in these pathways accentuates its importance in modulating inflammation and immune response.
Abnormalities in C3a regulation have notable implications. C3a is associated with various inflammatory and autoimmune diseases like asthma and rheumatoid arthritis. In asthma C3a interacts with other complement proteins such as C5a to exacerbate inflammation in the airways. Dysregulation of C3a and its conversion to C3a desArg may further contribute to pathologies implicating its potential as a therapeutic target in managing inflammatory diseases.