Abcam, ab36871, Anti-CTRP4 antibody

Size: 100µg
Rabbit Polyclonal CTRP4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human C1QTNF4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human C1QTNF4. The exact immunogen used to generate this antibody is proprietary information.Q9BXJ3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTRP4 also known as C1q and tumor necrosis factor-related protein 4 is a member of the C1q/TNF-related protein family. It has a molecular weight of approximately 31 kDa. The protein is expressed in various tissues including adipose tissue and the liver where it performs regulatory functions by interacting with other cellular components. Its presence in these tissues suggests roles in metabolism and inflammation.
Biological function summary
CTRP4 functions as a modulator of immune responses and energy balance. It is involved in forming complexes that can influence inflammatory pathways playing a part in controlling cytokine production. As a member of the CTRP family CTRP4 shares structural homology that allows it to interact with receptors implicated in metabolic and immune processes. This connection points to its role in maintaining homeostasis.
Pathways
CTRP4 participates in metabolic and inflammatory signaling networks. It engages in the AMPK signaling pathway which is critical for energy regulation. Within this context CTRP4 acts together with proteins like adiponectin to modulate glucose uptake and lipid metabolism. In the inflammatory landscape CTRP4 influences the MAPK signaling pathway affecting cellular responses to various stressors and regulatory signals.
CTRP4 has associations with obesity and type 2 diabetes. Its role in these conditions links to its function in metabolic regulation and inflammation control. For instance CTRP4 modulates inflammatory profiles connecting it with proteins such as TNF-alpha in the context of metabolic syndrome. Research continues to explore its potential as a therapeutic target given its involvement in these significant health challenges.