Abcam, ab400, Anti-hCG antibody [HCG1]

Size: 500µg
Mouse Monoclonal GLHA antibody. Suitable for ELISA, RIA, RID and reacts with Human samples. Cited in 9 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:HCG1,
Isotype:IgG1,
Light chain type:unknown,
Carrier free:No,
Reacts with:Human,
Applications:RID, ELISA, RIASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:hCG specifically recognises human chorionic gonadotropin. Its affinity for the free beta-chain is slightly greater than its affinity for the whole molecule.hCG - 100% hCG (beta) - 125% hCG (alpha) - <1% hLH - <1% hTSH - <0.05% hFSH - <0.1% Affinity constant: 5x109 l/mol HCG.

Product details:
Association Constant:
hCG: 4.0 x 10
and hCGbeta: 1.6 x 10
Dissociation Constant:
hCG: 1.4 x 10
and hCGbeta: 3.6 x 10
Affinity Constant hCG:
KA = 2.9 x 10
1/M; KD = 3.4 x 10
M (= 0.03 nM)
Affinity Constant hCGbeta:
KA = 4.4 x 10
1/M; KD = 2.3 x 10
M (= 0.23 nM)
Determination method:
SPR analysis
Antigen:
hCG; hCG-beta

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.1% Sodium azideConstituents: 0.9% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of two subunits alpha and beta. The beta subunit confers its specific biological activity. Its molecular weight ranges around 36.7 kDa. hCG is produced in the placenta during pregnancy and is also expressed in pituitary cells. Known alternatively as the pregnancy hormone hCG plays a critical role in maintaining the luteal function during the early stages of pregnancy.
Biological function summary
HCG regulates several functions related to reproduction. It supports the corpus luteum in ovaries to secrete progesterone during early pregnancy contributing to the uterine lining's maintenance. Moreover hCG can interact with the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) indicating its involvement in broader reproductive functions. Not as well known hCG may exist in various forms such as hCG intact influencing certain biological pathways differently.
Pathways
Scientists study hCG's role in reproductive signaling and gonadotropin pathways. It interacts closely with luteinizing hormone (LH) with substantial overlap in their pathway functions impacting reproductive health and fertility cycles. hCG's activation of specific receptors like LHCGR plays a role in these pathways connecting it to various fertility-related responses in the human body.
HCG levels can be an indicative marker for certain conditions. Elevated hCG levels may signal trophoblastic diseases such as molar pregnancy or gestational trophoblastic neoplasia. Its abnormal expression might also indicate testicular cancer where it acts as a tumor marker. Both conditions relate to hCG through its shared glycoprotein structure with other hormones like thyroid-stimulating hormone (TSH) which links the hormone to broader endocrine disorder research.