Abcam, ab4114, Anti-SNAP23 antibody

Size: 200µL
Rabbit Polyclonal SNAP23 antibody. Suitable for IHC-P, IP, WB, ICC/IF, IHC-Fr and reacts with Human, Mouse, Rat samples. Cited in 25 publications. Immunogen corresponding to Recombinant Protein within Human Synaptosomal-associated protein 23.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat, Mouse,
Applications:WB, IHC-P, IHC-Fr, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Protein within Human Synaptosomal-associated protein 23. The exact immunogen used to generate this antibody is proprietary information.O00161,
Specificity:This antibody reacts specifically with human SNAP23.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNAP23 also known as Synaptosomal-Associated Protein 23 is an important component in the mechanism of vesicular trafficking. It has a molecular mass of approximately 23 kDa and functions as a t-SNARE (target membrane SNAP receptor) protein. SNAP23 is expressed in various tissues with high expression levels in the brain pancreas liver and adipose tissue. This protein facilitates the fusion of vesicles with target membranes by forming SNARE complexes which are essential for the exocytosis and endocytosis processes.
Biological function summary
SNAP23 plays a significant role in the regulation of membrane fusion events and intracellular transport. It forms part of the SNARE complex which includes v-SNAREs on vesicle membranes and other t-SNAREs on target membranes. This complex orchestrates the docking and fusion of vesicles enabling the release of neurotransmitters and other cargoes in neuronal and non-neuronal cells. By mediating these events SNAP23 is important for neurotransmission insulin-regulated glucose uptake and other cellular processes.
Pathways
SNAP23 functions in the exocytotic and endocytic pathways where it aids in the accurate secretion and recycling of cellular components. It interacts with proteins like Syntaxin and VAMP (vesicle-associated membrane protein) to achieve precise vesicle targeting and fusion. SNAP23 is also implicated in insulin-signaling pathways where it modulates GLUT4 translocation to the cell surface a process vital for maintaining glucose homeostasis. These interactions underline its involvement in both neural communication and metabolic regulation.
SNAP23 has been associated with metabolic conditions such as type 2 diabetes and neurological disorders. The protein's function in insulin-regulated glucose transport suggests its relevance in diabetes where impaired glucose uptake occurs. In neurological contexts alterations in SNAP23 expression or function might contribute to disorders affecting synaptic transmission. Additionally its connection with proteins like GLUT4 and VAMP highlights SNAP23's role in disease contexts providing a linkage between vesicular transport and disease pathology.