Abcam, ab43032, Recombinant Rubella Virus gpE1 protein

Size: 200µg
Recombinant Rubella Virus gpE1 protein is a Rubella virus strain TO-336 Fragment protein, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P08564,
Animal free:No,
Carrier free:No,
Species:Rubella virus strain TO-336,
Storage buffer:Preservative: 0.14% ImidazoleConstituents: 48% Urea, 1.74% Sodium chloride

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Rubella Virus envelope glycoprotein E1 (gpE1) also known simply as E1 is an integral part of the rubella virus structure. This protein facilitates viral entry into host cells by mediating fusion with the cell membrane a critical step for viral infection. Structurally gpE1 is expressed on the surface of the rubella virus and has an approximate molecular weight of 58 kDa. This glycoprotein is predominantly found on the viral envelope where it performs its mechanical functions essential for initiating infection.
Biological function summary
The function of the envelope glycoprotein E1 lies in its association with the virus's infectivity and immune evasion capabilities. E1 forms a complex with another structural protein E2 contributing to the protective envelope of the virus. This protein complex is responsible for antigenic properties that help the virus to avoid detection by the host’s immune system. The interactions between gpE1 and host cell receptors play a significant role in the virus’ lifecycle by facilitating its entry into the host cells which is essential for successful replication and proliferation of the virus.
Pathways
Involvement of Rubella Virus gpE1 extends to its important roles in the viral entry and fusion pathways. The protein works in coordination with the viral envelope protein E2 to penetrate host immune defenses. This functional partnership allows gpE1 to participate actively in processes that facilitate the virus' survival and propagation within the host. The protein's mechanistic role in fusion pathways relates to its ability to induce cellular membrane fusion which is key for viral entry.
Rubella Virus gpE1 is directly linked to the pathogenesis of rubella infection which can cause serious outcomes like congenital rubella syndrome (CRS). This protein's interactions with immune system components are vital in the disease's development and progression. The inflammatory responses and pathologies associated with rubella infection are significantly influenced by gpE1 through its interactions with the host's immune recognition proteins such as CD46 which may act as a receptor for the virus. These interactions emphasize the protein's contribution to the virus's pathogenicity and the challenges it poses for medical intervention and vaccine development.