Abcam, ab48008, Anti-GALR3 antibody

Size: 200µL
Goat Polyclonal GALR3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GALR3 aa 300 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GALR3 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O60755

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 0.5% BSA, 0.05% Tris buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GALR3 also known as Galanin Receptor 3 is a G protein-coupled receptor with a mass of approximately 40 kDa. It is part of the galanin receptor family which consists of three members: GALR1 GALR2 and GALR3 itself. GALR3 is primarily expressed in the central nervous system and certain peripheral tissues. The receptor binds to the neuropeptide galanin and modulates various intracellular signaling pathways including inhibition of adenylate cyclase and modulation of ion channels.
Biological function summary
The interaction of GALR3 with galanin influences numerous physiological processes. GALR3 is not part of a known complex but functions independently to affect neural function. The receptor plays roles in modulating mood cognition and pain perception. It contributes to the regulation of neuroendocrine functions influencing hormone release and feeding behavior. GALR3's expression pattern and signaling capabilities suggest its involvement in fine-tuning nervous system responses.
Pathways
GALR3 is integrated into the neuropeptide signaling pathway and the G-protein signaling pathway. In the neuropeptide signaling pathway its interaction with galanin influences neurotransmitter release and synaptic plasticity. In the context of G-protein signaling GALR3 influences downstream effectors such as PLC and PI3K often working alongside related receptors like GALR1 and GALR2. These interactions reflect GALR3’s contribution to maintaining cellular homeostasis and response to external stimuli.
GALR3 shows relevance to several neuropsychiatric and metabolic conditions. Research indicates that GALR3 may play a role in depression where it modulates neurotransmitter release and synaptic plasticity. Its interaction with proteins like GALR1 and GALR2 is considered important here. Additionally GALR3 presents a connection to obesity due to its involvement in feeding behavior regulation and energy homeostasis. Understanding GALR3's role in these conditions can open avenues for therapeutic interventions targeting this receptor.