Abcam, ab49068, Recombinant HIV1 gp41 protein

Size: 100µg
Recombinant HIV1 gp41 protein is a Human immunodeficiency virus type 1 (BH8 ISOLATE) Fragment protein, in the 466 to 753 aa range, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P04582,
Animal free:No,
Carrier free:No,
Species:Human immunodeficiency virus type 1 (BH8 ISOLATE),
Storage buffer:pH: 7.2 - 7.6Constituents: 48% Urea, 0.316% Tris HCl, 0.078% 2-Mercaptoethanol

Product details:
Reacts strongly with human HIV positive serum.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HIV1 gp41 protein also known as the gp41 HIV protein is a glycoprotein that plays a mechanical role in the virus's capacity to fuse with host cells. This protein is 41 kDa in mass and is part of the viral envelope expressed on the surface of the HIV virus. Gp41 works closely with the gp120 protein to facilitate the fusion process a critical step in viral entry into lymphocytes. The 1d4 is sometimes used to refer to certain related domains or epitopes within the gp41 structure.
Biological function summary
During the infection process gp41 acts by mediating membrane fusion between the HIV viral envelope and the host cell membrane. It forms part of the Env complex consisting of gp120 and gp41 proteins which together create the functional envelope glycoprotein spike on the virus. This spike binds to receptors on the host cell such as the CD4 molecule which initiates changes that reveal the gp41 protein allowing it to insert into the host cell membrane and pull the viral and cellular membranes together.
Pathways
Involving HIV1 gp41 and its associated proteins the gp41 protein is a critical player in the viral entry pathway. After gp120 binds to the CD4 receptor and coreceptors such as CCR5 or CXCR4 on the host cell this conformational change exposes gp41 to carry out the fusion of viral and host membranes. The Env complex through gp41 and gp120 proteins coordinates this entry process integrating the viral genetic material with the host genome which is important for HIV propagation.
Involving the HIV1 gp41 protein it is directly related to the progression of HIV/AIDS. Gp41's function in viral entry makes it a target for antiviral drugs and vaccine development as inhibiting gp41 could block the virus from invading host cells. The interplay with gp120 and the interaction with host proteins like CD4 highlight the potential for gp41 as a therapeutic target in efforts to prevent or treat HIV infection.