Abcam, ab50322, Anti-MAFK antibody

Size: 50µL
Rabbit Polyclonal MAFK antibody. Suitable for WB and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human MAFK aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MAFK aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O60675

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAFK also known as Small Maf protein functions as a transcription factor involved in gene regulation. It has a molecular weight of approximately 18 kDa. This protein mainly acts as a repressor that binds to Maf recognition elements (MAREs) in DNA. Expression of MAFK occurs in various tissues including liver brain and lung. Its ability to form dimers further influences its regulatory activity enabling it to participate in diverse cellular processes.
Biological function summary
MAFK regulates transcription by forming heterodimers with other proteins such as the CNC-bZIP family members including NFE2L2 (also called NRF2). In these complexes MAFK modulates antioxidant response elements (ARE) gene expression. By controlling genes involved in oxidative stress responses MAFK plays an important role in maintaining cellular homeostasis. This functionality allows MAFK to impact a broad range of cellular activities reinforcing its importance in cellular responses to stress.
Pathways
MAFK is heavily involved in the oxidative stress response and the xenobiotic metabolism pathway. Through its interaction with NRF2 MAFK influences the cellular defense mechanism against oxidative damage highlighting its role in the NRF2-ARE pathway. Moreover MAFK also intersects with the heme degradation pathway where it collaborates with heme oxygenase 1 (HO-1) regulation. By participating in these pathways MAFK supports cellular adaptation to environmental changes.
MAFK has connections to cancer and neurodegenerative diseases. In various cancers altered MAFK expression impacts tumor growth and progression partly through NRF2-related pathways. Abnormal regulation of MAFK can also relate to disorders like Parkinson's disease where oxidative stress mechanisms are dysregulated. In these contexts the protein interacts with others like KEAP1 a regulator of NRF2 activity to influence disease development and progression.