Abcam, ab51075, Anti-MT4-MMP antibody [EP1270Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MT4-MMP antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 18 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1270Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MT4-MMP also known as matrix metalloproteinase 17 is a membrane-type metalloprotease. This protein has an approximate mass of 62 kDa and is anchored to the cell membrane by a GPI-anchor. MT4-MMP is expressed mainly in the brain and reproductive tissues suggesting its specialized roles across different regions. This protease belongs to the MMP family which consists of enzymes that can degrade extracellular matrix components and shows unique substrate specificities compared to other MMPs.
Biological function summary
MT4-MMP functions in tissue remodeling and extracellular matrix degradation. It does not typically form a part of larger protein complexes but works independently or in association with other cell surface molecules. MT4-MMP breaks down specific substrates contributing to processes like development reproduction and repair mechanisms. Its activity regulates the availability of bioactive molecules and extracellular matrix components impacting cellular behavior and tissue structure.
Pathways
MT4-MMP is involved in pathways critical for cell migration and angiogenesis. It participates in the activation of growth factors and modulates signaling pathways such as those related to integrins and vascular endothelial growth factor (VEGF). MT4-MMP associates with proteins like TIMP-2 which modulates its activity providing a regulatory mechanism within these pathways. This balance between activation and inhibition affects physiological and pathological tissue remodeling.
MT4-MMP has been implicated in cancer progression and arthritis. Its overexpression or dysregulation can lead to increased degradation of the extracellular matrix facilitating tumor invasion and metastasis. In arthritis its role in degrading connective tissue components contributes to joint destruction. MT4-MMP interacts with other MMPs and inhibitors like TIMP-2 influencing disease outcomes. Understanding these interactions can help in designing therapeutic strategies targeting MT4-MMP in such diseases.