Abcam, ab51132, Anti-CAB39/MO25 antibody [EP1680Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CAB39/MO25 antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 14 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1680Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAB39 also known as MO25 is a protein that plays an important role in cellular signaling. It has a mass of about 40 kDa and is predominantly expressed in the cytoplasm. CAB39 is part of the STE20-related kinase adaptor (STRAD) complex and functions to stabilize the scaffolding necessary for various kinase interactions. This protein is a subunit of the LKB1 complex essential for kinase activity. It modulates activity by binding to other proteins like STRAD and LKB1 enhancing their stability and function.
Biological function summary
CAB39 influences several cellular processes by acting as a scaffolding protein. It is an integral component of the LKB1-STRAD-MO25 complex essential for proper kinase activity. This complex regulates AMPK signaling pathways which are important for cellular energy homeostasis and metabolism. CAB39 by interacting with these kinases regulates energy balance within cells particularly muscle and liver tissues. This regulation influences cell polarity and growth impacting cell survival and division.
Pathways
CAB39 is significant in both the AMPK and mTOR signaling pathways playing a role in energy sensing and cellular growth regulation. In these pathways CAB39 modulates the activity of proteins like AMPK and LKB1. The AMPK pathway is important for maintaining energy homeostasis and is activated under low energy conditions while the mTOR pathway relates to cell growth and autophagy. CAB39’s role in these pathways highlights its importance in controlling metabolic responses to nutrient availability and stress.
CAB39 has implications in cancer and metabolic syndromes. Alterations in its function can disrupt normal AMPK and mTOR signaling leading to unchecked cell proliferation observed in cancer particularly in Peutz-Jeghers syndrome where LKB1 mutations are common. Additionally defects in CAB39-related pathways can lead to metabolic disorders like type 2 diabetes. By regulating AMPK activity CAB39 interacts indirectly with proteins such as PRKAA1 and PRKAA2 influencing insulin sensitivity and glucose metabolism.