Abcam, ab51137, Anti-MST3 antibody [EP1468Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MST3 antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 10 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1468Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Mammalian Sterile 20-like kinase 3 also known as MST3 or STK24 is a serine/threonine protein kinase with a mass of approximately 49 kDa. MST3 belongs to the STE20 group of kinases which play roles in various cellular processes. It localizes primarily in the cytoplasm and nucleus and sees significant expression in the brain heart liver and skeletal muscles. MST3 also associates with cellular structures such as the Golgi apparatus suggesting a role in intracellular transport or signaling.
Biological function summary
MST3 participates in regulating cell proliferation apoptosis and migration. It is not part of a larger complex but works closely with other signaling proteins to influence these processes. MST3 impacts cytoskeletal organization contributing to the dynamic remodeling of actin filaments. This protein also affects the apoptotic pathways by modulating the interactions with other kinases and apoptosis-related factors thereby aiding in the maintenance of cellular homeostasis.
Pathways
MST3 plays significant roles in the Hippo signaling pathway and the MAPK pathway—both critical for cell growth survival and differentiation. MST3 shares pathways with kinases like MOB1 and NDR1/2 in the Hippo pathway where it assists in regulating cell proliferation and apoptosis. In the context of MAPK signaling MST3 interacts with and is regulated by RAF1 and MEK1/2 coordinating cell stress responses and signaling cascades.
MST3 has associations with neurological disorders and cancer. In the context of neurological disorders MST3 activity affects neuronal apoptosis and tau phosphorylation processes that relate to neurodegenerative diseases. In cancer biology MST3 regulates apoptosis and proliferation and its dysregulation might contribute to tumorigenesis. MST3 connects with proteins such as BCL2 and PARP1 that also influence these disease states making it a protein of interest for therapeutic research.