Abcam, ab51324, Anti-CHD1L antibody [2170C3a]

Size: 50µg
Mouse Monoclonal CHD1L antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CHD1L.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2170C3a,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CHD1L. The exact immunogen used to generate this antibody is proprietary information.Q86WJ1

Product details:
This product was changed from ascites to tissue culture supernatant on 9
August 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from TCS, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CHD1L gene encodes a protein known as chromodomain helicase DNA-binding protein 1-like. This protein plays a role in chromatin remodeling using the energy from ATP hydrolysis to alter chromatin structure thereby facilitating processes such as DNA repair and transcription. The mass of CHD1L is approximately 120 kDa. This protein is expressed in various tissues with a notable presence in liver and cancerous tissues indicating its potential involvement in cellular proliferation and repair mechanisms.
Biological function summary
The function of CHD1L is significant in genomic stability and response to DNA damage. It acts as a part of the chromatin remodeling complex and contributes to the regulation of chromatin dynamics affecting gene expression and repair pathways. CHD1L interacts with other proteins involved in DNA repair ensuring the cell maintains genetic integrity under stress conditions.
Pathways
CHD1L is involved in the DNA damage response and chromatin organization pathways. It interacts with RAD51-associated protein which is important for homologous recombination repair and collaborates with proteins in the pathway to restore DNA integrity after damage. CHD1L's activity in these pathways highlights its role in maintaining cellular homeostasis and preventing genomic instability.
CHD1L has been implicated in hepatocellular carcinoma and ovarian cancer. The overexpression of CHD1L in such cancers suggests a role in cancer progression by promoting cell proliferation and survival. Additionally its interaction with HNF4A a protein involved in liver cancer accentuates its impact on oncogenic pathways. Understanding CHD1L in these contexts could offer insights into therapeutic targets for cancer treatment.