Abcam, ab51502, Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal

Size: 100µg
Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) is a mouse monoclonal antibody detecting SATB1 in Western Blot, IP . Suitable for Human, Mouse . - KO validated for confirmed specificity - Over 310 publications - Trusted since 2007
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SATBA4B10,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SATB2. The exact immunogen used to generate this antibody is proprietary information.Q9UPW6

Product details:
This product was changed from ascites to tissue culture supernatant on 9
August 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
Product Specifications
Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) is a mouse monoclonal antibody and is validated for use in ICC, IP, WB in human, mouse samples.
Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) specifically detects SATB1 +SATB2 (UniProt ID: Q01826; Molecular weight: 86kDa) and is sold in 100 µg selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) has high sensitivity and specificity.
The specificity of Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) has been confirmed by testing in knockout samples.
Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) has been cited over 314 times in peer reviewed journals and is trusted by the scientific community.
Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) has 17 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from TCS, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: 1% BSA, 0.812% Sodium chloride, 0.1136% Disodium hydrogenorthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SATB1 (Special AT-rich Binding Protein 1) and SATB2 are proteins that play key roles in chromatin organization. SATB1 is sometimes called "T lineage-restricted matrix attachment region protein" and it has a mass of around 85 kDa. SATB2 is similar in function with a mass of roughly 82 kDa. These proteins are expressed in various tissues with a high abundance in thymus and brain respectively. They function as transcription factors and have a unique ability to bind to matrix attachment regions (MARs) in the DNA organizing the chromatin into loops and regulating gene expression.
Biological function summary
SATB1 and SATB2 coordinate gene expression by modulating the chromatin architecture and acting as docking sites for various chromatin remodelers and transcription factors. SATB1 plays a significant role in T-cell development as well as regulation of genes included in apoptosis and differentiation processes. SATB2 on the other hand is important in skeletal development and neuronal differentiation. Membership of these proteins in large complexes allows them to influence various gene networks necessary for tissue-specific gene expression.
Pathways
SATB1 and SATB2 are essential components of the Wnt signaling pathway and Notch signaling pathway. In the Wnt pathway SATB1 interacts with β-catenin helping mediate downstream transcription activation of various genes involved in cell proliferation and differentiation. In the Notch pathway SATB2 influences the expression of genes related to cell fate decisions. These pathways highlight the connections of SATB1 and SATB2 with other proteins contributing to their regulatory capacities in cell identity and function.
SATB1 has been linked to breast cancer and systemic lupus erythematosus (SLE). Its overexpression in breast cancer correlates with increased tumor growth and metastasis suggesting its role in cancer progression. SATB2 connects to developmental disorders such as cleft palate and osteoporosis. This association relates to its function in craniofacial development and bone formation. Both SATB1 and SATB2 demonstrate overlapping functions with proteins like Runx2 in bone development and T-bet in immune regulation indicating their broader impact on health and disease.