Abcam, ab51602, Anti-ZIP Kinase antibody [EPR1636Y]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ZIP Kinase antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1636Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZIP Kinase also known as DAPK3 is a serine/threonine protein kinase with a molecular mass of approximately 52 kDa. It is expressed in a variety of tissues including the heart liver and skeletal muscle indicating its broad physiological importance. ZIP Kinase shows activity in phosphorylating specific substrates that influence cell structure and function playing a role in cellular processes.
Biological function summary
ZIP Kinase regulates apoptosis and autophagy impacting cell survival and homeostasis. It does not act in isolation but is part of a complex with other kinases and regulatory proteins. ZIP Kinase interacts with cytoskeletal proteins to mediate cell contraction and motility indicating its involvement in both normal cellular dynamics and stress responses.
Pathways
ZIP Kinase is involved in the apoptosis and autophagy pathways. Within the apoptosis pathway ZIP Kinase partners with proteins like DAPK1 influencing stress and injury responses. In the autophagy pathway it helps in regulating cellular degradation processes. These pathways allow ZIP Kinase to integrate signals that manage cell fate decisions collaboratively modulating cellular life and death.
ZIP Kinase associates with hypertension and certain types of cancer. In hypertension ZIP Kinase dysregulation may impact vascular smooth muscle cell contractility due to its connection with myosin light chain phosphorylation. In cancer altered ZIP Kinase activity may affect apoptosis linking it to aberrant cell proliferation. Its interaction with proteins like DAPK1 in both contexts underlines its role in pathological states where cell death and survival are disrupted.