Abcam, ab51957, Anti-SEMA5A antibody

Size: 200µL
Goat Polyclonal SEMA5A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SEMA5A aa 50-150.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SEMA5A aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q13591

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab51957 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SEMA5A also known as Semaphorin-5A is a member of the semaphorin family of proteins which guide axonal development and cell migration. This protein has a mass of approximately 89 kDa. SEMA5A is expressed in various tissues including the brain where it plays a significant part in neuronal development. It is a transmembrane protein with specific structural domains that facilitate its role in cell signaling affecting axonal guidance and cellular movement.
Biological function summary
SEMA5A functions in cell signaling mechanisms essential for proper neural circuit formation and development. The protein interacts with receptors on the cell surface including Plexin-B3 which serves as one of its main receptors and this interaction mediates axonal guidance. Not typically part of a larger complex SEMA5A still influences multiple biological processes such as cell adhesion and migration affecting how neurons connect and communicate in the central nervous system.
Pathways
SEMA5A operates within important signaling pathways like the semaphorin signaling pathway and the axon guidance pathway. These pathways play significant roles in neural development and involve key interactions with proteins like Plexins and Neuropilins. Within these pathways SEMA5A contributes to the establishment of neural connections and synaptic stability interacting with related proteins that direct cellular growth and structure formation.
Research associates SEMA5A with conditions such as autism spectrum disorder and certain types of cancer. Alterations in SEMA5A expression or function can contribute to neural connectivity irregularities observed in autism. Additionally SEMA5A shows involvement in cancer cell migration and invasion. Its interaction with Plexin-B3 can influence tumor progression and metastasis suggesting potential as a therapeutic target in disease management.