Abcam, ab52625, Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker

Size: 20µL / 100µL / 1mL
Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker (ab52625) is a rabbit monoclonal antibody detecting Cytokeratin 19 in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IHC-P, ICC/IF, mIHC . Suitable for Human, Mouse . - Multiplex IHC validated on the Leica BOND® MAX using Opal reagents - Biophysical QC for unrivalled batch-batch consistency - Over 230 publications - Trusted since 2007
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1580Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, Flow Cyt (Intra), mIHC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker (ab52625) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, WB and mIHC.
Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker (ab52625) was first used in a scientific publication in 2008 and has been cited over 231 times in peer reviewed journals. It's performance in IHC in mouse and human samples is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker (ab52625) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker (ab52625) has 13 independent reviews from customers.
Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker (ab52625) specifically detects Cytokeratin 19 (UniProt ID: P08727; Molecular weight: 45kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL).
Conjugation-ready, carrier free format available for antibody clone EP1580Y -
ab195872
Antibody clone EP1580Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor
488, Alexa Fluor
647, HRP, Alexa Fluor
594, Alexa Fluor
555, Alexa Fluor
568, APC, PE (
ab192643
ab192980
ab193600
ab203443
ab203444
ab203445
ab224980
ab224981
Cytokeratin 19 (CK19) is a protein marker used to identify epithelial cancers, particularly in the liver, pancreas and gastrointestinal tract, where its presence is often associated with aggressive tumor behaviour and poor prognosis; it is considered a valuable tool for diagnosing and assessing the potential aggressiveness of certain cancers, particularly when positive staining is observed in tumor cells.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cytokeratin 19 (CK19) also known as cytokera­tine 19 keratin 19 (KRT19) or CK19 is a type of intermediate filament found in epithelial cells. It serves as an essential component of the cytoskeleton. CK19 weighs approximately 40 kDa and is broadly expressed in simple epithelial tissues including liver intestine and various glandular epithelial cells. As a cytokeratin marker it often appears in combination with others like cytokeratin 17 in certain tissue types helping to maintain the structural integrity of cells.
Biological function summary
CK19 plays a role in maintaining the cytoskeletal framework that provides mechanical support and helps control cell size and shape. It is not part of a large protein complex but works closely with other cytokeratins to ensure the stability and resilience of epithelial tissues. The A53-B/A22.26 positive staining is often used to confirm its presence in clinical histopathology.
Pathways
CK19 connects to cellular processes especially involving the keratinization and epithelial cell differentiation pathways. It interacts with other cytokeratins including BA16 and KR17 to facilitate these processes. This interaction aids in modulating the dynamics of cytoskeletal rearrangement during cell movement division and differentiation.
CK19 overexpression is linked with certain cancers notably hepatocellular carcinoma and breast cancer. It can serve as a prognostic marker in these diseases often in conjunction with other markers like CK17. The involvement of CK19 in the epithelial-mesenchymal transition (EMT) process connects it to the progression and aggressiveness of tumors facilitated by interactions with proteins involved in EMT pathways.