Abcam, ab53006, Anti-EPS15R antibody [EP1147Y]

Size: 100µL
Rabbit Monoclonal EPS15R antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1147Y,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPS15R also known as Epidermal Growth Factor Receptor Pathway Substrate 15-Related Protein is a protein with a molecular mass of approximately 110 kDa. It acts mechanically as an adaptor protein playing significant roles in processes like endocytosis and cellular signaling. EPS15R contains several Epsin N-terminal Homology (ENTH) domains which allow it to interact with components of the clathrin-coated pits during vesicle formation. It is expressed broadly in human tissues with significant presence in the brain heart and skeletal muscles which hints at its varied functional roles.
Biological function summary
EPS15R participates in endocytosis where it influences the internalization of receptors and other molecules into cells. It forms part of a larger protein complex involved in cargo selection and vesicle budding often associating with proteins like epsin and clathrin. This interaction facilitates the concentration and packaging of signaling receptors therefore modulating signal transduction within the cell. EPS15R's role as an adaptor enables tight regulation of receptor trafficking ensuring coordinated cellular responses to external cues.
Pathways
EPS15R operates within the endocytic and ubiquitin-proteasome pathways where it modulates receptor-mediated endocytosis linked to signal transduction. In the endocytic pathway EPS15R interacts with proteins such as EGFR (Epidermal Growth Factor Receptor) helping to regulate EGFR internalization and degradation. This regulation is important for maintaining cellular homeostasis as it modulates the intensity and duration of signaling. EPS15R also associates with the ubiquitin-proteasome system through interactions with ubiquitin ligases which mark proteins for degradation and affect various signaling pathways.
EPS15R's dysregulation can contribute to neurodegenerative diseases and cancer. Altered endocytic trafficking due to EPS15R malfunction might play a role in diseases like Alzheimer's where defective protein clearance is observed. In cancer EPS15R's interactions with proteins like EGFR have implications in tumorigenesis as abnormal EGFR signaling due to misregulation at the endocytic level can promote unchecked cell proliferation. These associations emphasize EPS15R's potential as a therapeutic target for such diseases.