Abcam, ab53113, Anti-JM4/PRAF2 antibody

Size: 100µg
Rabbit Polyclonal JM4/PRAF2 antibody. Suitable for ELISA, WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:IHC-P, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JM4 also known as PRAF2 (PRA1 domain family member 2) is a small protein with a molecular mass of approximately 21 kDa. It is expressed mainly in the brain hinting at a role in neurological functions. PRAF2 contains several transmembrane domains and is localized primarily to the Golgi apparatus and endosomal structures within cells. This localization suggests potential involvement in intracellular trafficking processes.
Biological function summary
PRAF2 participates in several cellular mechanisms related to vesicular transport and signal transduction. It is not independently acting; rather it forms part of a complex that includes other PRA family members. By interacting with these proteins PRAF2 helps modulate cell signaling pathways that can impact neuronal communication and cellular responses. The roles in signaling and transport suggest PRAF2's importance for cellular homeostasis and neuronal function.
Pathways
PRAF2 plays roles in multiple important biological cascades such as the neuronal signaling and vesicular transport pathways. Within these processes its interaction with proteins like Rab GTPases is significant as these help regulate vesicle movement and neurotransmitter release. These interactions hint at PRAF2’s role in maintaining the proper function and dynamic balance necessary for neurological health.
Research implicates PRAF2 in conditions like glioblastoma and schizophrenia. Its upregulation has been observed in glioblastoma suggesting a possible role in tumor growth or progression. In schizophrenia altered PRAF2 expression may affect neurotransmitter systems aligning with symptoms of the disorder. Connections with related proteins such as PRAF1 and other Rab GTPases further highlight PRAF2's involvement in pathogenic processes that underline these diseases.