Abcam, ab53465, Anti-VEGF 164 antibody

Size: 50µL
Rabbit Polyclonal VEGFA antibody. Suitable for ELISA, WB, IHC-P, RIA and reacts with Rat, Pig, Human, Cow samples. Cited in 65 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Cow VEGFA.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Pig, Rat, Cow,
Applications:RIA, ELISA, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Cow VEGFA.P15691,
Specificity:ab53465 reacts with all human VEGF isoforms (121, 165, 189, and 206). No cross reaction is observed with PDGF, FGF-1, FGF-2, and TGFa.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
VEGF 164 also known as Vascular Endothelial Growth Factor 164 plays an important role in angiogenesis and vascular permeability. A member of the VEGF family it serves as a signal protein that promotes the growth of new blood vessels. Vegf 164 is expressed in various tissues and is specially important in the response to ischemic events and tissue remodeling. The molecular mass of VEGF 164 is approximately 45 kDa making it a protein of moderate size within its family.
Biological function summary
VEGF 164 is essential in cellular processes related to vascular growth and blood vessel formation. It is involved in endothelial cell proliferation migration and survival necessary steps for new blood vessel formation. The protein often functions as part of a larger complex that includes co-receptors like neuropilins enhancing its activity and specificity in various tissues. Overall its role is significant in maintaining the structural integrity of the vasculature.
Pathways
VEGF 164 is integrated into angiogenesis and wound healing pathways. It activates several signaling cascades including the PI3K/Akt and MAPK pathways which further involve related proteins like Akt1 and MAPK1. By mediating these pathways VEGF 164 ensures adequate nutrient and oxygen supply to growing tissues or responding to injury.
VEGF 164 has strong associations with cancer and age-related macular degeneration (AMD). In cancer it contributes to tumor growth and metastasis by aiding in the construction of new blood vessels that supply tumor cells. In AMD VEGF 164 levels can increase leading to abnormal blood vessel growth in the eye damaging vision. The protein interacts with similar function proteins like VEGF receptor 2 which is important in same pathological conditions.