Abcam, ab53720, Anti-RIT1/RIT antibody

Size: 100µg
Rabbit Polyclonal RIT1/RIT antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RIT1 also known as RIT or Ras-like without CAAX 1 is a small GTPase with a mass of approximately 21 kDa. It belongs to the Ras superfamily of proteins which are involved in signal transduction. RIT1 is widely expressed in various tissues including the brain where it plays a role in neuronal functions. Its structure and sequence share similarities with other Ras-related proteins although its regulatory mechanisms may differ.
Biological function summary
This protein regulates cell signaling pathways that control growth differentiation and survival. It does not exist alone but interacts with multiple effector proteins to exert its function. RIT1 has been implicated in protecting cells from stress-induced apoptosis suggesting its role in maintaining cell homeostasis. Researchers continue to examine how RIT1 modulates intracellular processes and its influence over cellular dynamics.
Pathways
The Ras/MAPK and PI3K/AKT signaling pathways are where RIT1 participates actively. The protein operates closely with MAP kinases which further regulate gene expression and cellular responses. In the PI3K/AKT pathway RIT1 facilitates the signaling required for cell survival and growth. Its interactions with these pathways highlight the influence it has on key regulatory proteins like AKT.
RIT1 mutations have associations with Noonan syndrome and certain cancers. Researchers have identified connections between RIT1 and other Ras pathway-related proteins such as KRAS and NRAS which are frequently mutated in similar conditions. Understanding these associations helps unravel RIT1's role in pathogenesis and highlights its value as a potential target for therapeutic interventions.