Abcam, ab53750, Anti-NUP93 antibody [3332C2a]

Size: 100µg
Mouse Monoclonal NUP93 antibody. Suitable for WB and reacts with Recombinant fragment samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NUP93.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:3332C2a,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NUP93. The exact immunogen used to generate this antibody is proprietary information.Q8N1F7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NUP93 also known as nucleoporin 93 is a protein with a molecular mass of approximately 93 kDa. It forms a part of the nuclear pore complex (NPC) specifically contributing to its structural integrity. NUP93 can be found in the nuclear envelope of eukaryotic cells where it aids in the proper functioning of the NPC. The protein ensures that macromolecules can efficiently transport between the nucleus and the cytoplasm therefore maintaining cellular function.
Biological function summary
NUP93 plays an important role in the assembly and stability of the nuclear pore complex by interacting with other nucleoporins. It is a component of the core scaffold structure interacting with proteins like NUP205 and NUP188 and helps in the spatial arrangement and functionality within the complex. Through these interactions NUP93 contributes to selective transport acting as gatekeeper to regulate traffic into and out of the nucleus.
Pathways
NUP93 influences various cellular processes by affecting nuclear transport pathways such as the nucleocytoplasmic transport pathway. Through its connectivity in the nuclear pore complex it affects the transit of molecules like messenger RNA (mRNA) and ribonucleoprotein complexes. NUP93 is associated with proteins such as importin-beta which is involved in the import of proteins with nuclear localization signals thereby ensuring precise nuclear-cytoplasmic communication.
Mutations or dysregulation of NUP93 have associations with nephrotic syndrome and some forms of cancer. Nephrotic syndrome can result from altered nuclear pore function where NUP93 links with proteins like podocin affecting kidney filtration efficiency. In cancer changes in nuclear transport potentially involving interactions with oncogenic proteins can disrupt cell cycle regulation and contribute to tumorogenic processes.