Abcam, ab56980, Anti-NMNAT2 antibody [2E4]

Size: 100µg
Mouse Monoclonal NMNAT2 antibody. Carrier free. Suitable for sELISA, IHC-P, Flow Cyt, WB, ICC/IF and reacts with Recombinant fragment, Human, Mouse samples. Cited in 18 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NMNAT2 aa 200 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2E4,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:Yes,
Reacts with:Human, Mouse,
Applications:sELISA, ICC/IF, IHC-P, WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NMNAT2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BZQ4

Product details:
This product was changed from ascites to tissue culture supernatant on 15th May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-Purified from TCS., Storage buffer-pH: 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NMNAT2 (nicotinamide nucleotide adenylyltransferase 2) is an enzyme that plays a role in the biosynthesis of NAD+ by converting nicotinamide mononucleotide (NMN) and ATP to NAD+ and pyrophosphate. It is also known in some contexts as NAD+ synthetase isoform 2. The molar mass of NMNAT2 is about 33 kDa. NMNAT2 expression occurs predominantly in the brain and nervous tissues where it contributes to cellular energy homeostasis and metabolism.
Biological function summary
NMNAT2 serves essential roles in maintaining NAD+ levels which are critical for numerous enzymatic processes within the cell including metabolism and cellular repair. This protein is not typically found as part of a larger complex but interacts with various cell compartments especially in neurons. NMNAT2 has been identified as an important player in axon maintenance and survival and it can protect against injury-induced degeneration.
Pathways
NMNAT2 is essential in the NAD+ biosynthesis pathway. It interfaces with several cellular functions tied to energy metabolism and repair processes. It often works alongside other related enzymes such as NAMPT (nicotinamide phosphoribosyltransferase) supporting the conversion of precursors into NAD+. NMNAT2 contributes to maintaining adequate energy levels within cells linking it closely with mitochondrial health and function.
NMNAT2 is implicated in neurodegenerative conditions such as Alzheimer's disease and axonopathy. Its role in the nervous system relates to the prevention of axonal degeneration making it an important focus for research into potential therapeutic targets. Reduced NMNAT2 activity has been linked with elevated risk of neuronal damage and degeneration where its interaction with proteins like tau known for their association with Alzheimer's pathogenesis is significant.