Abcam, ab58886, Anti-PER1 antibody [2715C2]

Size: 50µg
Mouse Monoclonal PER1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PER1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:2715C2,
Isotype:IgG1,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PER1. The exact immunogen used to generate this antibody is proprietary information.O15534

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PER1 protein also known as Period Circadian Protein Homolog 1 forms part of the circadian rhythm machinery. It has a molecular weight of approximately 136 kDa. This protein is expressed in various tissues including brain liver and muscle cells. Mechanically PER1 modulates the oscillations in the expression of core circadian clock genes. By binding to DNA PER1 regulates transcription and sets circadian rhythms stabilizing the biological clock.
Biological function summary
The PER1 protein plays a critical role in maintaining the body’s circadian cycles. It is part of a larger circadian clock complex that includes other components such as CLOCK and BMAL1. This protein ensures proper timing of sleep-wake cycles hormone release and other physiological processes. Although PER1 works with other proteins its individual expression influences the pace of the biological clock.
Pathways
PER1 protein functions within the circadian rhythm pathway and impacts the regulation of the sleep-wake cycle. It interacts with the CLOCK and CRY proteins contributing to the transcription-translation feedback loop fundamental for circadian timing. This complex interplay helps maintain synchronization with environmental light-dark cycles affecting various biological processes.
Abnormalities in PER1 expression associate with sleep disorders like familial advanced sleep phase syndrome (FASPS) and certain mood disorders. Disruptions in its regulatory network involving proteins like PER2 can lead to misalignments in circadian rhythms. These changes can result in issues with sleep patterns and contribute to mood regulation problems.