Abcam, ab59413, Anti-PKC mu/PKD (phospho S205) antibody

Size: 100µg
Rabbit Polyclonal PKC mu/PKD phospho S205 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PRKD1 phospho S205 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PRKD1 phospho S205 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.Q15139,
Specificity:Detects endogenous levels of PKC μ/PKD only when phosphorylated at serine 205 if Human or serine 203 if Mouse.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PKC mu also known as Protein Kinase D (PKD) is a serine/threonine protein kinase with a notable role in various cellular processes. It is also referred to as PKD 62 due to its molecular mass of approximately 62 kDa. This kinase expresses widely in human tissues with high levels observed in the liver skeletal heart muscle and pancreas. During key cellular actions PKC mu moves between different cellular compartments mediating essential signaling events.
Biological function summary
PKC mu influences several cellular processes including cell proliferation migration and survival. It forms part of a larger protein complex involved in diverse signaling pathways. PKC mu regulates gene expression by affecting various transcription factors. Its activity impacts pathways connected to cell growth and responses to stress demonstrating an essential role in maintaining cellular homeostasis.
Pathways
PKC mu plays an important role in both the MAPK and NF-kB signaling pathways. Through these pathways it interacts with proteins such as Ras and IKK contributing to cell growth and inflammation. PKC mu acts as a bridge allowing signals to be transmitted efficiently ensuring appropriate responses to extracellular stimuli.
PKC mu has been linked to cancer and cardiac hypertrophy. Alterations in PKC mu activity contribute to pathological states due to its involvement in pathways that manage cell growth and stress responses. For instance its overexpression or hyperactivity associates with tumor development and progression. PKC mu's relationship with proteins like Akt in cancer pathways further implicates it in oncogenic processes.