Abcam, ab59567, Anti-RPL26 + RPL26L1 antibody

Size: 50µL
Anti-RPL26 + RPL26L1 antibody (ab59567) is a rabbit polyclonal antibody detecting RPL26 in Western Blot, ICC/IF . Suitable for Human, Mouse, Rat . - Over 30 publications - Trusted since 2007
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RPL26 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P61254

Product details:
What is this antibody validated in?
Anti-RPL26 + RPL26L1 antibody (ab59567) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.
What is the molecular weight of RPL26?
Anti-RPL26 + RPL26L1 (ab59567) specifically detects a band for RPL26 (UniProt: P61254) at a molecular weight of 17kDa.
Trusted by the scientific community
Anti-RPL26 + RPL26L1 (ab59567) was first used in a scientific publication in 2007 and has been cited over 30 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPL26 also known as 60S ribosomal protein L26 or RPL26L1 is a component of the ribosome specifically part of the 60S large ribosomal subunit. It plays a role in ribosome biogenesis and protein synthesis. The molecular mass of RPL26 is approximately 17 kDa. It is expressed in a variety of tissues reflecting its fundamental role in protein production across different cell types. Expression levels might vary based on cellular activity and demands.
Biological function summary
RPL26 participates in the assembly and stabilization of ribosomal RNA and ribosome structure. It contributes to the formation of the ribosome complex important for translating mRNA into functional proteins. RPL26 interacts with multiple ribosomal proteins and other factors within the nucleolus to facilitate efficient ribosome production positioning it as an essential player in cellular growth and proliferation.
Pathways
RPL26 plays an integral role in the process of translation part of the broader cell cycle control and growth regulation pathways. It is associated with the p53 signaling pathway which involves regulation of the cell cycle and response to DNA damage through interactions with proteins such as MDM2. These interactions highlight its involvement in cellular responses to stress and damage linking ribosomal function with regulation of cell survival mechanisms.
Mutations or dysregulation of RPL26 have been connected to certain cancers with studies indicating its role in tumor progression in conditions like breast cancer. Furthermore alterations in RPL26 expression or function may contribute to ribosomopathies disorders that involve defects in ribosome function leading to conditions like Diamond-Blackfan Anemia. In these contexts RPL26 interacts with tumor suppressor proteins like p53 highlighting its influence on cell growth and apoptosis in disease states.