Abcam, ab6034, Anti-4E-T antibody

Size: 100µg
Goat Polyclonal 4E-T antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human EIF4ENIF1 aa 950 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EIF4ENIF1 aa 950 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NRA8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 4E-T protein also known as eIF4E-Transporter plays a critical role in translational regulation by controlling the localization and function of eIF4E an important component of the mRNA cap-binding complex. The mass of 4E-T is approximately 103 kDa. It is expressed in various tissues including the brain and testis suggesting its involvement in diverse physiological processes. The protein collaborates with eIF4E to facilitate or repress translation of specific mRNAs affecting gene expression at the translational level.
Biological function summary
4E-T regulates mRNA metabolism and translation serving as a modulator within the cell. It forms a complex with eIF4E and other translation repressors such as DEAD-box helicase DDX6 and Pat1 protein which then associates with mRNA to influence its translational state. This interaction enables 4E-T to impact gene expression by selectively binding and sequestering capped mRNAs therefore blocking their translation initiation at ribosomes.
Pathways
4E-T is involved in the mTOR signaling pathway which is essential for cell growth and metabolism. It also plays a role in the stress response pathway known as the nonsense-mediated mRNA decay pathway. In these pathways 4E-T interacts with proteins like LSm1 and UPF1 coordinating the cellular response to nutrient availability and stress and contributing to the degradation of faulty mRNA.
4E-T has been implicated in cancer and neurodegenerative diseases. In cancer its regulation of mRNA translation and interaction with proteins like eIF4G can affect tumor cell growth and survival. In neurodegenerative diseases alterations in its regulation can influence neuron health with its association with proteins like CPEB impacting synaptic plasticity and memory. Understanding 4E-T's involvement in these diseases provides avenues for potential therapeutic targets.