Abcam, ab60854, Recombinant human FGR protein

Size: 5µg / 10µg
Recombinant human FGR protein is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>95% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Active,
Accession:P09769,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0038% EGTA, 0.00292% EDTA, 0.00174% PMSF

Product details:
ab204877
(Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FGR protein also known as Src-like adapter protein or FGR proto-oncogene is an important cellular component with a mass of approximately 58 kDa. Expressed mainly in hematopoietic cells like macrophages and neutrophils the FGR protein belongs to the Src family of non-receptor tyrosine kinases. This protein has the ability to modulate various cellular processes through its kinase activity influencing the phosphorylation of substrates involved in signal transduction.
Biological function summary
The FGR protein impacts processes related to immune responses and cell communication. It participates in the formation of multi-protein complexes enabling interactions that mediate pathways important for cellular signaling. Through these interactions the FGR protein controls important processes like cell growth differentiation and movement especially in immune cell types. Its role in signal transduction renders it a critical player in various immune functions.
Pathways
The FGR protein integrates into the signaling networks such as the MAPK/ERK pathway and PI3K/AKT pathway which are pivotal for cell survival and proliferation. Within these pathways FGR interacts with other proteins like the GRB2 and PI3K to mediate downstream effects that influence many cellular responses. These interactions ensure that alterations in external signals lead to appropriate cellular outcomes sustaining a balance in cellular behavior and immune functions.
Alterations in the expression or mutation of the FGR protein have associations with certain cancers and inflammatory diseases. Enhanced FGR activity has been observed in specific leukemia cases where its interaction with proteins like ABL1 and BCR-ABL1 contributes to oncogenic processes. Similarly abnormalities in FGR signaling pathways can result in immune dysfunctions implicating proteins like Lyn and Hck in pathologies such as rheumatoid arthritis. Understanding the role of FGR within disease contexts aids in identifying therapeutic targets for these conditions.