Abcam, ab60873, Recombinant human PKC mu/PKD protein

Size: 5µg / 10µg
Recombinant human PKC mu/PKD protein is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, WB, FuncS.
Key facts
Purity:>90% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:FuncS, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Active,
Accession:Q15139,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0038% EGTA, 0.00292% EDTA, 0.00174% PMSF

Product details:
ab204856
(CREB peptide) can be utilized as a substrate for assessing kinase activity
This product was previously labelled as PKC mu

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PKC mu also known as Protein Kinase D (PKD) is a serine/threonine protein kinase with a notable role in various cellular processes. It is also referred to as PKD 62 due to its molecular mass of approximately 62 kDa. This kinase expresses widely in human tissues with high levels observed in the liver skeletal heart muscle and pancreas. During key cellular actions PKC mu moves between different cellular compartments mediating essential signaling events.
Biological function summary
PKC mu influences several cellular processes including cell proliferation migration and survival. It forms part of a larger protein complex involved in diverse signaling pathways. PKC mu regulates gene expression by affecting various transcription factors. Its activity impacts pathways connected to cell growth and responses to stress demonstrating an essential role in maintaining cellular homeostasis.
Pathways
PKC mu plays an important role in both the MAPK and NF-kB signaling pathways. Through these pathways it interacts with proteins such as Ras and IKK contributing to cell growth and inflammation. PKC mu acts as a bridge allowing signals to be transmitted efficiently ensuring appropriate responses to extracellular stimuli.
PKC mu has been linked to cancer and cardiac hypertrophy. Alterations in PKC mu activity contribute to pathological states due to its involvement in pathways that manage cell growth and stress responses. For instance its overexpression or hyperactivity associates with tumor development and progression. PKC mu's relationship with proteins like Akt in cancer pathways further implicates it in oncogenic processes.