Abcam, ab61200, Anti-KCNA3 antibody

Size: 100µg
Rabbit Polyclonal KCNA3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KCNA3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human KCNA3. The exact immunogen used to generate this antibody is proprietary information.P22001

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab61200 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KCNA3 also known as Kv1.3 is a voltage-gated potassium channel that plays a part in controlling membrane potential in cells. It consists of a protein with a mass of approximately 57 kDa. KCNA3 is mainly expressed in the immune system particularly in T lymphocytes macrophages and microglia. Its expression also extends to the central nervous system where it helps regulate neuronal excitability.
Biological function summary
This potassium channel contributes to the activation and proliferation of T cells. It typically forms a complex with other ion channels to coordinate cellular responses to stimuli. KCNA3 regulates calcium signaling and helps balance the cell's internal environment by facilitating potassium efflux providing support for various immune functions.
Pathways
KCNA3 is involved in both the immune response and intracellular signaling pathways. It plays roles in pathways like the calcium signaling pathway and the MAPK signal transduction cascade. Through these pathways it often interacts with other proteins such as calcium release-activated calcium (CRAC) channels to maintain cellular homeostasis and function.
KCNA3 has associations with autoimmune conditions like multiple sclerosis and rheumatoid arthritis. Dysfunction in KCNA3's regulation of T cell activity can lead to abnormal immune responses. It's linked with the protein CTLA-4 which is another immune checkpoint molecule involved in autoimmune pathologies. This makes KCNA3 a potential target for therapy in related autoimmune diseases.