Abcam, ab62024, Anti-Nogo A antibody

Size: 100µg
Rabbit Polyclonal RTN4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 24 publications. Immunogen corresponding to Synthetic Peptide within Human RTN4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human, Rat,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RTN4. The exact immunogen used to generate this antibody is proprietary information.Q9NQC3,
Specificity:ab62024 is specific for Nogo A and Nogo E.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nogo-A protein also known simply as Nogo Nogo A or Nogo-A plays a significant role in the central nervous system as an inhibitor of neurite outgrowth. It has a molecular mass of approximately 200 kDa. Nogo-A is predominantly expressed in the oligodendrocytes of the central nervous system and it functions as a myelin-associated inhibitor regulating the growth and direction of nerve fibers. This protein is important for maintaining the stability of mature neural networks by preventing excessive sprouting and misguided growth of axons.
Biological function summary
Protein Nogo-A restricts neuronal regeneration and plasticity which can be observed during development and in adult nervous system tissues. It is part of the Nogo-66 receptor complex which includes receptors like NgR1. The interaction with its receptor complex triggers RhoA signaling pathways leading to the inhibition of cytoskeletal dynamics that are necessary for axon extension. This inhibition tends to stabilize synaptic connections and helps in maintaining the structural integrity of the nervous system.
Pathways
Nogo-A impacts the signaling pathways that are involved in axonal guidance and neuronal regeneration. The protein participates prominently in the RhoA/ROCK pathway which is responsible for regulating cytoskeletal formation and dynamics. Nogo-A is also related to the p75 neurotrophin receptor pathway which influences cell survival and apoptosis. These pathways collectively contribute to the regulation of neural growth and plasticity by modulating actin cytoskeleton structure in response to extrinsic inhibitory signals.
Protein Nogo-A is significantly linked to conditions such as spinal cord injury and multiple sclerosis. In spinal cord injury Nogo-A acts as a barrier to nerve regeneration hindering the recovery of motor and sensory functions. Similarly in multiple sclerosis Nogo-A may contribute to the failure of remyelination and nerve repair. Research often explores Nogo-A's interaction with proteins like NgR1 which could provide therapeutic avenues for counteracting its inhibitory effects in these neurological disorders.