Abcam, ab63301, Recombinant Human Osteocrin protein

Size: 100µg
Recombinant Human Osteocrin protein is a Human Fragment protein, in the 28 to 133 aa range, expressed in Escherichia coli, with >95%, suitable for WB.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P61366,
Animal free:No,
Carrier free:No,
Species:Human,
Reconstitution:Reconstitute at 0.5 mg/mL in 0.1 M acetate buffer, pH 4.0,
Storage buffer:Constituents: 0.145% Sodium chloride, 0.0605% Tris

Product details:
Product is NOT sterile! Please filter the product by an appropriate sterile filter before using it in cell culture.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Osteocrin also known as OSTN is a small secreted protein with an approximate molecular mass of 13 kDa. It is expressed highly in certain tissues such as bone and muscle. Osteocrin acts mechanically by binding to natriuretic peptide receptor-C (NPR-C). This interaction plays a substantial role in mediating various physiological responses.
Biological function summary
Osteocrin participates in the modulation of bone growth and muscle activity. It exists as part of a non-complex pathway serving as a regulatory molecule for natriuretic peptides. Osteocrin modulates the effects of natriuretic peptides by preventing their binding to clearance receptors which increases their bioavailability and prolonged action. This action impacts vascular physiology and growth regulation.
Pathways
Osteocrin plays a significant role in the natriuretic peptide signaling pathway. In this pathway it functions closely with proteins such as ANP (atrial natriuretic peptide) and BNP (brain natriuretic peptide). These proteins engage in blood pressure and volume regulation by causing vasodilation and promoting natriuresis. Osteocrin modulates the effectiveness of this pathway through its interaction with NPR-C enhancing the functions by extending the half-life of the active peptides involved.
Researchers have identified osteocrin's involvement in cardiovascular conditions and osteoporosis. Osteocrin's ability to enhance natriuretic peptide availability has implications for managing cardiovascular diseases where these peptides play protective roles. Additionally osteocrin influences bone density suggesting a connection to osteoporosis. Interactions with proteins like NPR-C and BNP are critical in these conditions with osteocrin modulating their biological activity and potentially offering therapeutic benefits.