Abcam, ab63638, Anti-PKC epsilon antibody

Size: 100µg
Rabbit Polyclonal KPCE antibody. Suitable for ELISA, WB, IHC-P, ICC/IF, IHC-Fr and reacts with Mouse, Rat, Human samples. Cited in 13 publications. Immunogen corresponding to Synthetic Peptide within Human PRKCE.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ELISA, ICC/IF, IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PRKCE. The exact immunogen used to generate this antibody is proprietary information.Q02156

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab63638 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein kinase C epsilon (PKC epsilon) also known as PKCε or epsilon protein is an important serine/threonine kinase involved in various cellular processes. It has a molecular weight of about 87 kDa. PKC epsilon is widely expressed in different tissues prominently in the brain heart skeletal muscle and endocrine tissues. It belongs to the novel PKC subfamily that responds to diacylglycerol and phospholipids without requiring calcium for activation.
Biological function summary
PKC epsilon plays roles in regulating cell survival migration and apoptosis. It is involved in forming signalling complexes with proteins such as receptor for activated C kinase (RACK) and frequently associates with scaffolding proteins. PKC epsilon contributes to the modulation of cytoskeletal reorganization exocytosis and neurotransmitter release impacting cellular communication and function significantly.
Pathways
PKC epsilon is integrated into significant signalling cascades including the MAPK/ERK and PI3K/Akt pathways. These pathways influence cell proliferation differentiation and survival. PKC epsilon interacts with proteins like Raf-1 and Akt further modulating signals for cellular responses. Its activity and interactions within these pathways highlight its importance in maintaining cellular homeostasis.
PKC epsilon has connections to cancer and cardiovascular diseases. It plays a part in oncogenic processes such as tumorigenesis and metastasis often working alongside proteins like PI3K in these contexts. In cardiovascular conditions PKC epsilon influences cardiac hypertrophy and ischemic heart damage. Its role associating with proteins such as endothelial nitric oxide synthase (eNOS) illustrates its involvement in disease mechanisms where blood flow and myocardial function are affected.