Abcam, ab63860, Anti-Myeloid Precursor Cells antibody [ER-MP58]

Size: 125µg
Rat Monoclonal Myeloid Precursor Cells antibody. Suitable for Flow Cyt, IHC-Fr, IP, ICC/IF and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing Myeloid Precursor Cells protein.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:ER-MP58,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse,
Applications:Flow Cyt, IHC-Fr, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Myeloid precursor cells also known as myeloid progenitors are important cells in hematopoiesis the process through which blood cells form. These cells have a role in early stages of differentiation that lead to various myeloid lineages like granulocytes monocytes erythrocytes and platelets. Myeloid precursors are found primarily in the bone marrow which is their site of origin and where they proliferate and differentiate. The molecular mass of these cells is not typically defined because they represent a cell population rather than a single molecular entity.
Biological function summary
Myeloid precursor cells are involved in generating the immune system's innate components. They initiate the formation of cells that function in first-line defense against pathogens. While myeloid precursors are not part of a specific protein complex they are integrally related to their progeny which perform various biological roles ranging from phagocytosis and antigen presentation to oxygen transport. These cells carry important markers and signaling pathways that guide their differentiation and function.
Pathways
Myeloid precursor cells participate in critical signaling networks that regulate hematopoiesis such as the JAK-STAT and MAPK pathways. These pathways influence cell survival proliferation and differentiation decisions. Myeloid precursors interact with key proteins such as colony-stimulating factors (CSFs) and interleukins influencing their trajectory into specific myeloid cells. Understanding these pathways aids in deciphering the complex patterns of lineage commitment and differentiation.
Myeloid precursor cells have significant implications in conditions like leukemia and myelodysplastic syndromes. These cells may undergo malignant transformations leading to uncontrolled proliferation as seen in acute myeloid leukemia (AML). Aberrant signaling through pathways involving proteins such as FLT3 and RUNX1 can result in these conditions. Research into how myeloid precursors contribute to these disorders provides insights into potential therapeutic targets for treating hematological malignancies.