Abcam, ab63917, Anti-HIV1 p55 + p24 + p17 antibody

Size: 100µL
Anti-HIV1 p55 + p24 + p17 antibody (ab63917) is a rabbit polyclonal antibody detecting HIV1 p55 + p24 + p17 in Western Blot, ELISA . Suitable for Human immunodeficiency virus . - Over 30 publications - Trusted since 2008
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human immunodeficiency virus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What is this antibody validated in?
Anti-HIV1 p55 + p24 + p17 antibody (ab63917) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), ELISA in Human immunodeficiency virus samples.
Trusted by the scientific community
Anti-HIV1 p55 + p24 + p17 (ab63917) was first used in a scientific publication in 2008 and has been cited over 30 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-pH: 6 - 8.5Preservative: 0.09% Sodium azideConstituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
'HIV1 p55' alternatively known as 'p55 HIV' 'p55 tax form' or 'p55.fun' is a precursor polyprotein composed of the matrix protein p17 the capsid protein p24 and other smaller proteins. This polyprotein with a molecular mass of approximately 55 kDa is expressed in HIV-infected cells. It is integral to the HIV virus structure providing the necessary framework for subsequent protein processing and assembly of viral particles. Researchers commonly use products like anti-HIV antibodies and techniques such as western blot for detection and study of this protein.
Biological function summary
HIV1 p55 serves as an essential component in the assembly and maturation of viral particles. It undergoes cleavage by the viral protease to form the individual proteins including p17 and p24 essential for the structural integrity of the HIV virus. These components play specific roles within the viral life cycle; p24 forms the viral core while p17 is involved in regulating viral RNA packaging. Together they contribute to the membrane budding process completing the virus assembly essential for its replication and infection.
Pathways
HIV1 p55 participates in critical viral infection pathways including the retroviral replication cycle. Protein processing and maturation by the viral protease involve interactions with other viral proteins like the reverse transcriptase and integrase facilitating the integration of viral DNA into the host genome. This process connects HIV1 p55 indirectly to host cellular pathways such as the MAPK signaling pathway influencing viral replication and pathogenesis within the host immune system.
HIV1 p55 is closely related to HIV/AIDS with its proteins playing central roles in disease progression. The HIV infection leading to acquired immunodeficiency syndrome (AIDS) involves the interplay of viral proteins including p17 and p24 with the host's immune response. Detection of p24 in diagnostic assays remains a standard indicator for assessing HIV infection levels in patients. As part of HIV pathogenesis these proteins heavily influence immune system evasion and persistence within the host presenting potential targets for antiretroviral therapy development.