Abcam, ab64739, Anti-DRAM antibody [M3-P4B4]

Size: 100µg
Mouse Monoclonal DRAM antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:M3-P4B4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The DRAM (Damage-Regulated Autophagy Modulator) protein also known by its alternate name "drum" plays a significant role in the regulation of autophagy. DRAM serves as an effector molecule that interacts with specific molecular pathways to control cell self-digestion processes. Its molecular weight falls within the range typical for small regulatory proteins. Expression of DRAM mainly occurs in various tissues with a higher presence observed in human epithelial tissues.
Biological function summary
DRAM facilitates the autophagy process which is critical for cellular homeostasis and balancing the degradation and recycling of cellular components. It functions closely with other autophagy-related proteins forming part of a complex that includes well-studied regulators like ULK1 and LAMP2. The modulation of autophagic activity by DRAM has implications for both normal cellular processes and the response to cellular stresses.
Pathways
The product of the DRAM gene integrates into the autophagic mechanisms where it acts to enhance degradation of defective proteins and organelles. It has associations within the p53 signaling pathway through which it mediates apoptosis and autophagy. Proteins such as p53 and BCL-2 are closely related to the action of DRAM influencing cellular fate decisions during stress conditions.
DRAM's role in autophagy links it to cancer and neurodegenerative diseases. Upregulated DRAM expression is frequently observed in tumor cells where it may influence cancer progression by modulating cell survival pathways. Additionally dysregulated autophagy involving DRAM has connections to Alzheimer's disease potentially due to interactions with proteins like APP which undergo autophagic degradation processes that this protein modulates.