Abcam, ab64805, Anti-GTF2IRD1 antibody

Size: 100µg
Rabbit Polyclonal GTF2IRD1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GTF2IRD1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GTF2IRD1. The exact immunogen used to generate this antibody is proprietary information.Q9UHL9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GTF2IRD1 also known as General Transcription Factor II-I repeat domain-containing protein 1 is a transcription factor involved in gene regulation. It has a molecular mass of around 122 kDa. The protein expresses widely in several tissues including the brain heart and skeletal muscle. GTF2IRD1 directly interacts with DNA to modulate transcriptional activity acting as an important regulator in the control of gene expression by binding to specific target sequences.
Biological function summary
GTF2IRD1 influences cellular development and differentiation. It is found as part of a larger transcriptional complex essential for its function in regulating genes involved in neural development and craniofacial structure. By influencing these developmental processes GTF2IRD1 helps in maintaining structural integrity and functional capabilities of cells particularly in the nervous system.
Pathways
GTF2IRD1 connects with multiple molecular pathways including the MAPK signaling pathway where it influences various downstream effects important for cellular responses. It also interacts with components like MAPK1 and other related proteins further integrating into the transcriptional regulatory network. The modulation of these signaling cascades highlights GTF2IRD1's important role in cellular signaling and response.
Abnormal expression or mutations in GTF2IRD1 associate with Williams-Beuren syndrome a developmental disorder characterized by growth delays and cardiovascular problems. Its interactions with proteins like ELN (elastin) and LIMK1 in the genetic region affected by the syndrome suggest a mechanism for the diverse symptoms. Further understanding of GTF2IRD1 interactions presents potential opportunities for targeted therapeutic interventions in related disorders.