Abcam, ab64809, Anti-ACRBP antibody

Size: 100µg
Rabbit Polyclonal ACRBP antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ACRBP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ACRBP. The exact immunogen used to generate this antibody is proprietary information.Q8NEB7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACRBP also known as SP32 or cancer/testis antigen 14 is a microtubule-associated protein with an approximate mass of 25 kDa. It operates in cellular processes promoting stability in the microtubule structure. ACRBP expresses strongly in the testis and is scarcely found in other normal tissues. However its expression is notable in various cancers particularly in tumors such as ovarian and breast cancers.
Biological function summary
This protein plays a significant role in cell division by stabilizing microtubules during mitosis. ACRBP does not function alone as it is part of a larger complex involving microtubules aiding in their organization and dynamics. This stabilization ensures proper chromosome segregation and successful cell division which remains especially important in proliferative tissues and malignancies.
Pathways
ACRBP is important in the regulation of the cell cycle particularly in the progression of the G2/M phase. Its activity associates with significant signaling pathways involved in cell proliferation and mitotic spindle formation. ACRBP interacts with proteins like TUBB and enhances their function within these pathways influencing the assembly and disassembly of the mitotic spindle during cell division.
ACRBP's aberrant expression or malfunction links closely to cancer progression specifically in ovarian and lung cancers. Its association with malignant cell proliferation and chemotherapy resistance highlights its importance in tumor biology. Furthermore ACRBP connects with proteins like MAGE-A enhancing their oncogenic potential and influencing treatment outcomes in associated cancers.