Abcam, ab64866, Anti-MZF1 antibody

Size: 100µg
Rabbit Polyclonal MZF1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human MZF1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MZF1. The exact immunogen used to generate this antibody is proprietary information.P28698

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MZF1 also known as Myeloid Zinc Finger 1 functions as a transcription factor. It has a molecular mass of around 75 kDa. This protein binds to DNA sequences and regulates the transcription of specific genes. Researchers frequently find MZF1 in myeloid cells but it also appears in a variety of tissues to a lesser extent. It plays an important role in controlling gene expression in these environments contributing to cellular development and differentiation.
Biological function summary
MZF1 regulates the expression of several genes involved in cellular proliferation and differentiation particularly within the hematopoietic system. It acts as a driving force behind the differentiation of myeloid progenitor cells into mature forms. The protein does not form part of a complex but interacts with other transcription factors to modulate gene expression. Its function is linked to cellular processes like development responding to signals that dictate cell fate.
Pathways
MZF1 has implications in cell cycle regulation and apoptotic pathways. It interacts with pathways involving the cell cycle helping to control the transition through various phases ensuring proper cell division. MZF1 correlates with proteins like c-Myc and p53 adding to regulatory networks that maintain cellular homeostasis. Its role is therefore central in maintaining normal cellular function and growth by participating in these critical pathways.
MZF1 has associations with cancer particularly leukemia due to its expression in myeloid lineage cells. It influences the expression of oncogenes and tumor suppressor genes with c-Myc often playing a cooperative role in these conditions. Researchers also link MZF1 to neurodegenerative disorders as aberrant expression can impact cellular survival and death pathways. This highlights MZF1's potential as a target for therapeutic strategies given its involvement in important regulatory networks and disease processes.