Abcam, ab64943, Anti-GRK5 antibody

Size: 100µg
Rabbit Polyclonal GRK5 antibody. Suitable for IHC-P, ELISA, WB, ICC/IF, IHC-Fr and reacts with Human, Mouse, Rat samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human GRK5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat, Mouse,
Applications:WB, IHC-P, ELISA, IHC-Fr, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GRK5. The exact immunogen used to generate this antibody is proprietary information.P34947

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GRK5 also known as G protein-coupled receptor kinase 5 plays an important role in the regulation of G protein-coupled receptors (GPCRs). This kinase phosphorylates activated receptors leading to desensitization and internalization. GRK5 has a molecular weight of approximately 68 kDa. Researchers find its expression in various tissues including heart brain and leukocytes with high levels in the heart. Its expression pattern suggests it has essential roles in cardiovascular and neural functions.
Biological function summary
The kinase modulates receptor signaling and is involved in regulating the sensitivity of cells to external signals. It is part of the GRK family which includes several kinases that modulate receptor signaling through phosphorylation. GRK5 interacts with plasma membrane receptors and can form part of larger signaling complexes. This interaction helps control processes such as cellular communication and response to environmental changes.
Pathways
GRK5 plays critical roles in signaling pathways like the beta-adrenergic signaling pathway and the regulation of blood pressure. It's closely related to other proteins such as GRK2 (also known as βARK1) which also participates in receptor desensitization. These pathways underline its involvement in cardiovascular regulation and adaptation to stimulus alterations. GRK5’s action in these pathways provides a balance in cellular responses to sustained signaling activity.
Alterations in GRK5 influence cardiovascular diseases including heart failure and hypertension. Changes in GRK5 expression or function can lead to improper regulation of blood pressure and heart rate demonstrating its significant role in maintaining cardiovascular health. Additionally the protein has links to neurodegenerative diseases such as Alzheimer’s where altered receptor activity and signaling imbalance occur. This kinase interacts with other proteins like β-amyloid precursor protein in neural tissues indicating its role in neural health and disease progression.