Abcam, ab6506, Anti-HSV1 + HSV2 gB antibody [10B7]

Size: 100µg
Anti-HSV1 + HSV2 gB antibody [10B7] (ab6506) is a mouse monoclonal antibody detecting HSV1 + HSV2 gB in Western Blot, ICC/IF . Suitable for Herpes simplex virus, Human herpesvirus 2 . - Over 30 publications - Trusted since 2001
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:10B7,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:Yes,
Reacts with:Herpes simplex virus, Human herpesvirus 2,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What is this antibody validated in?
Anti-HSV1 + HSV2 gB antibody [10B7] (ab6506) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Herpes simplex virus, Human herpesvirus 2 samples.
Trusted by the scientific community
Anti-HSV1 + HSV2 gB [10B7] (ab6506) was first used in a scientific publication in 2001 and has been cited over 30 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The glycoprotein B (gB) of Herpes Simplex Virus type 1 (HSV1) and type 2 (HSV2) is an important viral protein responsible for membrane fusion during viral entry and cell-to-cell spread. This protein is referred to as gB in both HSV1 and HSV2 contexts. Glycoprotein B has an approximate molecular mass of 110 kDa and is expressed on the surface of the viral envelope. It is highly conserved across alpha-herpesviruses. HSV1 and HSV2 gB play critical roles in the herpesvirus infection cycle facilitating the virus's ability to infect cells and spread within the host.
Biological function summary
Glycoprotein B facilitates the fusion of the viral envelope with the host cell membrane which is essential for viral entry. gB functions as part of a complex with other glycoproteins particularly gD gH and gL to mediate this fusion process. The interaction between gB and these glycoproteins is important for the virus to penetrate host cells. The conserved structure of gB allows it to participate in membrane fusion events that enable the virus to escape immune detection and maintain infection in the host.
Pathways
Glycoprotein B of HSV1 and HSV2 interacts with cellular signaling pathways that influence viral entry and immune evasion. gB is a part of the fusion machinery essential for the fusion pathway working closely with other fusion-associated proteins such as gH and gL. It is integrated into the herpesvirus life cycle including viral replication and spread. The interaction of gB with cellular receptors on the host cell membrane exemplifies its role in co-opting host cellular mechanisms to facilitate viral transmission and infection.
HSV1 and HSV2 gB is associated with herpes simplex infections leading to conditions like oral herpes (HSV1) and genital herpes (HSV2). Glycoprotein B's role in viral entry makes it a target for therapies aimed at preventing herpes virus transmission. The protein's association with gD gH and gL is significant in the context of developing antiviral drugs and vaccines designed to disrupt the fusion process and reduce the severity of herpes-related symptoms. Understanding gB's function provides insights into potential therapeutic strategies against herpes simplex virus infections.