Abcam, ab65128, Anti-CYP2U1 antibody

Size: 100µg
Rabbit Polyclonal CYP2U1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Cytochrome P450 2U1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Cytochrome P450 2U1. The exact immunogen used to generate this antibody is proprietary information.Q7Z449

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP2U1 also known as Cytochrome P450 2U1 is an enzyme belonging to the cytochrome P450 family which plays an essential role in hydroxylation reactions and fatty acid metabolism. The protein has a mass of approximately 57 kDa. CYP2U1 is expressed mainly in brain thymus and liver tissues where its enzymatic activity modulates various metabolic processes.
Biological function summary
CYP2U1 processes long-chain fatty acids into hydroxy-fatty acids which are important for various cellular functions. It does not function as part of a larger enzyme complex but operates independently to influence lipid metabolism and energy balance in cells. This activity of CYP2U1 impacts physiological processes such as inflammation and neuronal health.
Pathways
CYP2U1 participates in the arachidonic acid and linoleic acid metabolism pathways. These pathways are significant because they link to the biosynthesis of important signaling molecules that mediate inflammatory responses and cell communication. CYP2U1 interacts with related proteins like CYP2C19 and CYP2J2 which also contribute to fatty acid metabolism.
Mutations or dysfunctions in CYP2U1 have connections with hereditary spastic paraplegia (HSP) and a specific type of cerebellar ataxia. HSP mutations in CYP2U1 affect neuronal pathways critical for motor function. In cerebellar ataxia CYP2U1 dysfunction affects proteins like spastin which result in impaired motor coordination and balance. Understanding CYP2U1's role in these disorders offers insights into potential therapeutic strategies.