Abcam, ab65164, Anti-SCN3A antibody

Size: 100µL
Rabbit Polyclonal SCN3A antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SCN3A aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SCN3A aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q9NY46

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCN3A also known as sodium channel voltage-gated type III alpha subunit or NaV1.3 plays a mechanical role in the conduction of electrical signals in excitable cells. It forms part of the voltage-gated sodium channels that are critical in the generation and propagation of action potentials. SCN3A has a molecular mass of approximately 260 kDa and is expressed broadly in the central nervous system particularly in neurons.
Biological function summary
The voltage-gated sodium channel SCN3A contributes to rapid depolarization in neuronal action potentials. It is an important component of a larger sodium channel complex which includes beta subunits that regulate the kinetic properties and localization of these channels. This enables proper neuronal signaling and communication affecting processes such as neurotransmission and response to stimuli.
Pathways
SCN3A influences the regulation of neuronal excitability and synaptic activity. It operates within the action potential pathway and has connections to the calcium signaling pathway which impacts numerous cellular processes. SCN3A functions alongside proteins such as SCN1A and SCN2A within these pathways contributing to the integrated organization of electrical signaling in neurons.
Mutations or dysregulations in SCN3A relate to epilepsy and neurodevelopmental disorders. SCN3A's interaction with SCN1A is significant as alterations in sodium channel function can lead to imbalance in neuronal excitability and seizures. These relationships highlight the importance of SCN3A in maintaining normal neural function and its potential as a therapeutic target in related neurologic conditions.