Abcam, ab65218, Anti-SERINC3 antibody

Size: 100µg
Rabbit Polyclonal SERINC3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab65218 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SERINC3 also known as serine incorporator 3 is a protein that incorporates serine into lipid membranes to assist in the biosynthesis of phosphatidylserine. It is a protein of approximately 53 kDa. The protein expresses widely including in the brain lung liver and kidney indicating its importance across different tissues. It is an integral membrane protein with roles involving lipid metabolism and membrane organization.
Biological function summary
Serine incorporation and lipid composition integrity depend heavily on SERINC3. It facilitates the proper synthesis of phosphatidylserine by promoting the transfer of serine to the lipid bilayer. This activity makes SERINC3 essential for the structural and functional stability of cell membranes. Although it functions individually SERINC3 can influence the formation of membrane complexes by altering lipid environments conducive to protein assembly.
Pathways
Serine metabolism and lipid biosynthesis prominently involve SERINC3. It integrates into the serine biosynthesis pathway interplaying with enzymes like phosphatidylserine synthase. Furthermore SERINC3 affects phosphatidylinositol signaling pathways by modulating phosphatidylserine levels which are precursors for secondary messengers. This interconnection highlights its relationship with other proteins such as phosphatidylserine synthase and reveals its contributory role in signaling cascades.
Researchers associate SERINC3 with viral infections and neurological conditions. Its alteration affects HIV-1 infectious processes by blocking the incorporation of viral particles into functional lipid membranes hinting at an antiviral role. Additionally some studies link it to schizophrenia as changes in membrane phospholipids can influence neural functions. In both cases its interactions with viral proteins or neural lipid metabolism highlight its potential therapeutic relevance.