Abcam, ab67018, Anti-AGPAT1 antibody

Size: 50µg
Mouse Polyclonal AGPAT1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human AGPAT1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human AGPAT1.Q99943

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AGPAT1 also known as 1-acylglycerol-3-phosphate O-acyltransferase 1 performs an important role in lipid biosynthesis. It catalyzes the conversion of lysophosphatidic acid into phosphatidic acid a precursor for glycerolipid synthesis. The molecular mass of AGPAT1 is approximately 28 kDa. AGPAT1 expresses widely in human tissues with higher levels seen in adipose tissue liver and heart.
Biological function summary
AGPAT1 impacts lipid metabolism and energy homeostasis. It participates as a single enzyme and is not typically part of larger protein complexes. By facilitating the production of phosphatidic acid it influences the balance of lipid intermediates necessary for membrane and lipoprotein synthesis. This activity affects cellular processes like membrane dynamics and signal transduction.
Pathways
AGPAT1 plays an integral role in the glycerolipid metabolism pathway. It collaborates with enzymes like lipin-1 to regulate pathways that control lipid storage and release. Its action supports the phosphatidic acid pathway which connects to various cellular signaling cascades. AGPAT1 cooperates with other proteins that modulate lipid signals bringing about effects on cell proliferation and survival.
AGPAT1 associates notably with metabolic disorders and cardiovascular diseases. Dysregulation of AGPAT1 has implications for conditions like obesity and atherosclerosis as improper lipid metabolism can lead to excess lipid accumulation or energy imbalance. AGPAT1's interaction with proteins such as lipin-1 influences these disorders where lipid imbalance and chronic inflammation become important factors.