Abcam, ab67325, Anti-TMC6 antibody

Size: 100µg
Rabbit Polyclonal TMC6 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMC6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TMC6. The exact immunogen used to generate this antibody is proprietary information.Q7Z403

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMC6 also known as EVER1 is a protein implicated in the regulation of metal ion transport across cellular membranes. The protein has a molecular mass of approximately 89 kDa. TMC6 is widely expressed in several tissues with notable expression levels in keratinocytes and epithelial cells. It localizes to the endoplasmic reticulum membrane suggesting its involvement in ion homeostasis processes within the cell.
Biological function summary
The protein plays a significant role in maintaining cellular zinc levels. TMC6 is part of a complex with another protein called TMC8 involved in metal ion transport and potentially influencing immune response processes. This complex is essential for cellular metal homeostasis and disruptions in its function can lead to imbalances affecting cellular health. Its presence in keratinocytes suggests a particular importance in skin health and function.
Pathways
TMC6 interacts with the zinc regulation pathway which is essential for numerous cellular processes including enzyme function and gene expression. It also has connections to the immune response pathway where it might modulate responses influenced by metal ion levels. Within these pathways TMC8 often works alongside TMC6 to modulate the balance of zinc ions illustrating the close functional relationship between TMC6 and TMC8.
TMC6 is closely linked to skin disorders particularly epidermodysplasia verruciformis (EV) a rare condition that predisposes individuals to skin lesions and human papillomavirus (HPV) infections. Mutations in TMC6 can impair the immune system's ability to control HPV infections contributing to disease manifestation. This relationship highlights the interaction between TMC6 and HPV proteins illustrating its key role in maintaining skin integrity and immune defense against viral infections.