Abcam, ab67682, Anti-KLHL20 antibody

Size: 50µg
Mouse Polyclonal KLHL20 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLHL20.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human KLHL20.Q9Y2M5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLHL20 also known as Kelch-like protein 20 is a substrate adaptor protein with a molecular mass of approximately 68 kDa. It is part of the BTB-Kelch protein family and participates in forming E3 ubiquitin ligase complexes. KLHL20 plays a role in mediating the ubiquitination and degradation of protein substrates. This protein is mainly expressed in various tissues including the brain liver and kidney.
Biological function summary
KLHL20 functions importantly in protein homeostasis and cellular regulatory mechanisms. It forms a complex with Cullin 3 and functions as a part of the CRL3 E3 ligase complex where it aids in targeting specific proteins for ubiquitination and degradation. By regulating protein turnover KLHL20 modulates cellular processes such as cell cycle progression and apoptosis.
Pathways
KLHL20 interacts with vital cellular processes such as the ubiquitin-proteasome system (UPS) and oxidative stress response. Its involvement in the UPS facilitates the removal of misfolded proteins helping to maintain cellular protein quality control. KLHL20 interacts closely with proteins like KEAP1 which is a regulator of the Nrf2 pathway therefore playing a role in antioxidative responses.
KLHL20 has implications in cancer and neurodegenerative diseases. Altered expression or function of KLHL20 may lead to disruptions in protein degradation pathways contributing to tumor progression and neuronal damage. In cancer KLHL20's regulatory impact on cell cycle proteins links it with tumor suppressor proteins like p53. In neurodegenerative conditions connections with proteins involved in protein aggregation make KLHL20 an important component in understanding these disorders.