Abcam, ab67714, Anti-CAMLG/CAML antibody

Size: 50µg
Mouse Polyclonal CAMLG/CAML antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CAMLG.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CAMLG.P49069

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CAMLG also known as CAML (calcium modulating ligand) is a protein with a molecular mass of approximately 37 kDa. CAMLG has an essential role in cellular calcium signaling processes. It is predominantly expressed in the endoplasmic reticulum membrane in various cell types. CAMLG's function involves mediating calcium influx and maintenance which affects multiple cellular operations. The protein interacts with membrane-bound elements facilitating its role in signaling and cellular homeostasis.
Biological function summary
CAMLG contributes to proper cellular signaling and function by managing calcium flux. It is part of larger protein complexes that regulate calcium-dependent cellular activities. CAMLG assists in the modulation of intracellular calcium levels that influence processes like cell proliferation differentiation and apoptosis. As part of its complex interactions CAMLG collaborates with other proteins involved in calcium signal transduction.
Pathways
Cellular calcium homeostasis mechanisms feature CAMLG as a critical component. This protein functions within pathways such as the NFAT (nuclear factor of activated T-cells) signaling and IP3 (inositol 145-trisphosphate) pathway. In these systems CAMLG interacts with other proteins like IP3 receptor affecting the release and regulation of calcium ions which impact gene transcription and immune response.
Dysfunction in CAMLG activity relates to immune system irregularities and cancer. Disruption in calcium signaling pathways implicates CAMLG in conditions like autoimmune disorders affecting immune cell regulation. Abnormal expression or mutations in CAMLG may also contribute to cancerous cell proliferation when linked to proteins such as NFAT emphasizing its involvement in oncogenic pathways.